DMT-2'-F-dG(dmf)-CE Phosphoramidite IVT a 5’-dimethoxytrityl (DMT) group for

a 5’-dimethoxytrityl (DMT) group for 5’-hydroxyl protection

Delivers high coupling efficiency and consistently strong crude yields

where m1Ψ provides stronger suppression of innate immune responses and supports robust protein expression in vivo

and a isobutyryl (iBu) base-protecting group on guanine

[3] Mouritzen

DMT-2'-F-dG(dmf)-CE Phosphoramidite IVT a 5’-dimethoxytrityl (DMT) group forDMT 2 F dG(dmf) CE Phosphoramidite is a 2' fluoro (2' F) phosphoramidite monomer used for solid phase oligonucleotide synthesis. It contains a 2' F modification on the sugar of deoxyguanosine (dG) with dimethylformamidyl (dmf) base protection, a 5 dimethoxytrityl (DMT) group for 5' hydroxyl protection, and a cyanoethyl (CE) protecting group on phosphite. Synthesis of RNA oligonucleotides using 2' F phosphoramidite increases the nuclease resistance and